Yin Fei, Liu Jianhui, Deng Xiaohong, Wang Jingyun
Research Center of Pharmaceutical Chemistry & Chemobiology, Chongqing Technology and Business University, Chongqing 400067, China.
J Biochem. 2007 May;141(5):669-74. doi: 10.1093/jb/mvm069. Epub 2007 Mar 4.
The increasing data show that a parallel G-quadruplex structure formed by the element of nuclease-hypersensitivity element III(1) (NHE III(1)) in the P1 promoter of c-myc functions as a transcriptional repressor. Triethylene tetraamine has exhibited interesting properties of stabilizing both inter- and intra-molecular G-quadruplex structures and telomerase-inhibitory potency. Here, we present evidences showing that triethylene tetraamine facilitates the formation of G-quadruplex structure by the NHE III(1) element, and inhibits the expression of c-myc in HeLa cells.
越来越多的数据表明，c-myc基因P1启动子中核酸酶高敏元件III(1)（NHE III(1)）形成的平行G-四链体结构作为转录抑制因子发挥作用。三亚乙基四胺已表现出稳定分子间和分子内G-四链体结构以及端粒酶抑制活性的有趣特性。在此，我们提供证据表明三亚乙基四胺促进NHE III(1)元件形成G-四链体结构，并抑制HeLa细胞中c-myc的表达。
