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解析G-四链体与天然/合成多胺之间的相互作用

Deciphering the Interplay Between G-Quadruplexes and Natural/Synthetic Polyamines.

作者信息

Gil-Martínez Ariadna, Galiana-Roselló Cristina, Lázaro-Gómez Andrea, Mulet-Rivero Laura, González-García Jorge

机构信息

Department of Inorganic Chemistry, Institute of Molecular Science, University of Valencia, Catedrático José Beltrán 2, 46980, Paterna, Spain.

Príncipe Felipe Research Center, Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.

出版信息

Chembiochem. 2025 Apr 1;26(7):e202400873. doi: 10.1002/cbic.202400873. Epub 2024 Dec 23.

DOI:10.1002/cbic.202400873
PMID:39656761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12002122/
Abstract

The interplay between polyamines and G-quadruplexes has been largely overlooked in the literature, even though polyamines are ubiquitous metabolites in living cells and G-quadruplexes are transient regulatory elements, being both of them key regulators of biological processes. Herein, we compile the investigations connecting G-quadruplexes and biogenic polyamines to understand the biological interplay between them. Moreover, we overview the main works focused on synthetic ligands containing polyamines designed to target G-quadruplexes, aiming to unravel the structural motifs for designing potent and selective G4 ligands.

摘要

多胺与G-四链体之间的相互作用在文献中很大程度上被忽视了，尽管多胺是活细胞中普遍存在的代谢产物，而G-四链体是瞬时调节元件，它们都是生物过程的关键调节因子。在此，我们汇总了将G-四链体与生物源多胺联系起来的研究，以了解它们之间的生物学相互作用。此外，我们概述了主要致力于设计靶向G-四链体的含多胺合成配体的研究工作，旨在揭示设计有效且选择性的G4配体的结构基序。

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本文引用的文献

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Interaction of G-quadruplex Forming DNA Aptamers with PAMAM Dendrimers Studied by Dynamic Light Scattering and UV-VIS Spectrophotometry.通过动态光散射和紫外可见分光光度法研究 G-四链体形成 DNA 适体与 PAMAM 树枝状大分子的相互作用。
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Development of potent tripodal G-quadruplex DNA binders and their efficient delivery to cancer cells by aptamer functionalised liposomes.
强效三脚架型G-四链体DNA结合剂的开发及其通过适配体功能化脂质体向癌细胞的高效递送。
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Click-Chemistry-Based Biomimetic Ligands Efficiently Capture G-Quadruplexes and Help Localize Them at DNA Damage Sites in Human Cells.基于点击化学的仿生配体可有效捕获G-四链体并帮助将其定位在人类细胞的DNA损伤位点。
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Dye-functionalized phosphate-binding macrocycles: from nucleotide to G-quadruplex recognition and "turn-on" fluorescence sensing.染料功能化的磷酸结合大环：从核苷酸到 G-四链体识别和“开启”荧光传感。
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