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一种用于研究土拉弗朗西斯菌活疫苗株在非吞噬细胞中黏附和侵袭的体外模型系统。

An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells.

作者信息

Lindemann Stephen R, McLendon Molly K, Apicella Michael A, Jones Bradley D

机构信息

Department of Microbiology, University of Iowa School of Medicine, 51 Newton Road, Iowa City, IA 52242-1109, USA.

出版信息

Infect Immun. 2007 Jun;75(6):3178-82. doi: 10.1128/IAI.01811-06. Epub 2007 Mar 5.

DOI:10.1128/IAI.01811-06
PMID:17339345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1932879/
Abstract

In observing Francisella tularensis interactions with nonphagocytic cell lines in vitro, we noted significant adherence, invasion, and intracellular growth of the bacteria within these cells. F. tularensis live vaccine strain invasion of nonprofessional phagocytic cells is inhibited by cytochalasin D and nocodazole, suggesting that both the actin and microtubule cytoskeletons are important for invasion.

摘要

在体外观察土拉弗朗西斯菌与非吞噬细胞系的相互作用时，我们注意到这些细胞内细菌有显著的黏附、侵袭及细胞内生长现象。细胞松弛素D和诺考达唑可抑制土拉弗朗西斯菌活疫苗株对非专职吞噬细胞的侵袭，这表明肌动蛋白和微管细胞骨架对侵袭均很重要。

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