Stankoff B, Mrejen S, Tourbah A, Fontaine B, Lyon-Caen O, Lubetzki C, Rosenheim M
Centre d'Investigation Clinique, AP-HP, Hôpital Pitié-Salpêtrière-UPMC, Paris, France.
Neurology. 2007 Mar 6;68(10):779-81. doi: 10.1212/01.wnl.0000256732.36565.4a.
We investigated the influence of age at disease onset on timing of the progressive phase in 957 patients with multiple sclerosis (MS). Age at onset powerfully predicts the probability of developing a primary progressive form of the disease. Moreover, age at onset strongly determines the time to conversion to secondary progression for patients presenting with a relapsing form. This suggests that age at onset strongly influences the neurodegenerative component of MS.
我们研究了957例多发性硬化症（MS）患者发病年龄对疾病进展期时间的影响。发病年龄有力地预测了发展为原发性进行性疾病形式的可能性。此外，发病年龄强烈决定了复发型患者转变为继发性进展的时间。这表明发病年龄强烈影响MS的神经退行性成分。
