Plutzky Jorge
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Postgrad Med. 2003 Apr;113(4 Suppl):15-23. doi: 10.3810/pgm.04.2003.suppl26.136.
Diabetes mellitus is a disorder involving multiple metabolic abnormalities that significantly increase risk of coronary heart disease (CHD). Although most typically associated with dysregulated glucose, diabetes also leads to dyslipidemia, often characterized by elevated triglyceride levels, low highdensity lipoprotein cholesterol levels, and a preponderance of small, dense low-density lipoprotein particles. Subgroup analyses of long-term studies show that therapy with 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (ie, "statins") significantly reduces risk of major CHD events in patients with diabetes as well as those with impaired fasting glucose.
糖尿病是一种涉及多种代谢异常的疾病，会显著增加冠心病（CHD）的风险。虽然糖尿病最常与血糖调节异常相关，但它也会导致血脂异常，其特征通常是甘油三酯水平升高、高密度脂蛋白胆固醇水平降低以及存在大量小而密的低密度脂蛋白颗粒。长期研究的亚组分析表明，使用3-羟基-3-甲基戊二酰辅酶A抑制剂（即“他汀类药物”）进行治疗可显著降低糖尿病患者以及空腹血糖受损患者发生主要冠心病事件的风险。
