Soen Satoshi
Kinki University School of Medicine, Nara Hospital, Department of Orthopaedic Surgery and Rheumatology.
Clin Calcium. 2007 Mar;17(3):399-402.
The use of systemic corticosteroids is one of independent risk factors with bone mineral density (BMD) for fractures. The prior and current exposure to corticosteroids confers an increased risk of fracture that is of substantial importance beyond that explained by the decrease of BMD. Cut-off value of lumbar BMD for vertebral fractures was 80% of young adult mean in Japanese patients. For management of glucocorticoid-induced osteoporosis, we have to concern about all risk factors of fracture including BMD and use the evidence-based guideline.
全身使用糖皮质激素是导致骨折的骨密度（BMD）独立危险因素之一。既往和当前使用糖皮质激素会增加骨折风险，这一风险的重要性远超过因骨密度降低所解释的部分。在日本患者中，椎体骨折的腰椎骨密度临界值为年轻成人平均值的80%。对于糖皮质激素诱导的骨质疏松症的管理，我们必须关注包括骨密度在内的所有骨折危险因素，并采用循证指南。
