Chatterjee P K
Department of Pharmacology and Therapeutics, School of Pharmacy & Biomolecular Sciences, University of Brighton, UK.
Br J Pharmacol. 2007 Apr;150(8):961-2. doi: 10.1038/sj.bjp.0707185. Epub 2007 Mar 5.
In this issue of British Journal of Pharmacology, Megías and colleagues demonstrate how preincubation of human colonic Caco-2 cells with CORM-2, a carbon monoxide releasing molecule (CO-RM), reduces the expression of inducible nitric oxide synthase, interleukin (IL)-6 and IL-8 caused by proinflammatory cytokines. A role for IL-6 in the regulation of metalloproteinase (MMP)-7 expression by CORM-2 is described. However, it is the demonstration that CORM-2 inhibits MMP-7 or matrilysin expression, which is most intriguing as this small MMP has been implicated in carcinogenesis. Thus, CO-RMs appear to now possess chemoprotective properties and, in this particular case, may influence inflammation-induced colon carcinogenesis via modulation of nuclear factors participating in the transcription of genes implicated in the development of intestinal inflammation and cancer. This report opens yet another door for research involving these exciting molecules and it is now clear that further discoveries of the beneficial properties of CO-RMs will go on.
在本期《英国药理学杂志》中，梅吉亚斯及其同事展示了用一氧化碳释放分子（CORM）-2对人结肠Caco-2细胞进行预孵育，如何降低促炎细胞因子引起的诱导型一氧化氮合酶、白细胞介素（IL）-6和IL-8的表达。描述了IL-6在CORM-2调节金属蛋白酶（MMP）-7表达中的作用。然而，最引人关注的是CORM-2抑制MMP-7或基质溶素表达的证明，因为这种小的MMP与致癌作用有关。因此，一氧化碳释放分子似乎现在具有化学保护特性，在这种特殊情况下，可能通过调节参与肠道炎症和癌症发展相关基因转录的核因子来影响炎症诱导的结肠癌发生。本报告为涉及这些令人兴奋的分子的研究打开了另一扇门，现在很清楚，一氧化碳释放分子有益特性的进一步发现将会继续。
