Fonzo D, Lauro R, De Martinis C
Department of Medical Pathology and Clinical Methodology, University of Turin, Italy.
Arch Sci Med (Torino). 1972 Oct-Dec;129(4):215-22.
The influence of estradiol and of two electron donors (succinate and malate) on testosterone metabolism was studied in vitro. In presence of estradiol the metabolic pattern of testosterone in male liver was changed to a female pattern. On the contrary, addition of malate or succinate to the female liver incubate gave origin to polar metabolites of testosterone which are typical of the male metabolic pattern.
在体外研究了雌二醇和两种电子供体（琥珀酸和苹果酸）对睾酮代谢的影响。在存在雌二醇的情况下，雄性肝脏中睾酮的代谢模式转变为雌性模式。相反，向雌性肝脏培养液中添加苹果酸或琥珀酸会产生睾酮的极性代谢产物，这些产物是雄性代谢模式所特有的。
