Grootendorst Paul, Marshall Deborah, Pericak Dan, Bellamy Nicholas, Feeny David, Torrance George W
Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
J Rheumatol. 2007 Mar;34(3):534-42.
To develop a formula to translate Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores collected in clinical trials of patients with osteoarthritis (OA) into Health Utilities Index Mark 3 (HUI3) utility scores for application in economic evaluation.
Data from a previously published open-label randomized controlled trial of appropriate care with hylan G-F 20 versus appropriate care without hylan G-F 20 in 255 outpatients with knee OA. We estimated linear regression models of HUI3 scores using various functions of WOMAC, demographics, and clinical variables. Out-of-sample predictive performance of the models was assessed using the mean absolute error and several other criteria.
The preferred formula included WOMAC pain, stiffness, function subscales, demographic variables; it accounted for almost 40% of the variation in the HUI3 utility scores. At the group level, absolute differences between predicted and actual overall HUI3 utility scores were < 0.001 and not statistically significantly different from zero.
A formula was derived from the WOMAC index to estimate overall utility scores based on the HUI3 for studies of patients with OA for whom utility has not been recorded. Researchers can estimate overall utility scores, compute quality-adjusted life-years, and perform cost-utility analyses within a defined range of certainty.
制定一个公式，将骨关节炎（OA）患者临床试验中收集的西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分转换为健康效用指数Mark 3（HUI3）效用评分，以用于经济评估。
数据来自之前发表的一项开放标签随机对照试验，该试验对255例膝关节OA门诊患者进行了透明质酸G-F 20适当治疗与无透明质酸G-F 20适当治疗的比较。我们使用WOMAC、人口统计学和临床变量的各种函数估计HUI3评分的线性回归模型。使用平均绝对误差和其他几个标准评估模型的样本外预测性能。
首选公式包括WOMAC疼痛、僵硬、功能分量表、人口统计学变量；它解释了HUI3效用评分中近40%的变异。在组水平上，预测的和实际的总体HUI3效用评分之间的绝对差异<0.001，且与零无统计学显著差异。
从WOMAC指数中推导了一个公式，用于基于HUI3估计未记录效用的OA患者研究的总体效用评分。研究人员可以估计总体效用评分，计算质量调整生命年，并在确定的范围内进行成本效用分析。
