Dhar K K, DAS N, Brinkman D A, Beynon J L, Woolas R P
Department of Gynaecological Oncology, Saint Mary's Hospital, Portsmouth, United Kingdom.
Int J Gynecol Cancer. 2007 May-Jun;17(3):720-3. doi: 10.1111/j.1525-1438.2007.00885.x. Epub 2007 Mar 2.
Sentinel node (SN) biopsy is widely applied for treatment planning of cutaneous melanoma. However, using this strategy in female lower genital tract tumors has not yet been established. We report two cases, one each of vulvar and vaginal melanoma who underwent SN biopsy and review the available literature. Our experience and available limited evidence suggests that this low morbidity technique can be used for obtaining prognostic information and hence treatment planning for this disease. However, a false negative rate perhaps in the order of 15% suggests that careful consideration is necessary before using sentinel lymph node biopsy in the management of vulvar and vaginal melanoma.
前哨淋巴结（SN）活检广泛应用于皮肤黑色素瘤的治疗规划。然而，在女性下生殖道肿瘤中采用这种策略尚未确立。我们报告两例病例，分别为1例外阴黑色素瘤和1例阴道黑色素瘤，均接受了前哨淋巴结活检，并回顾了现有文献。我们的经验及有限的现有证据表明，这种低发病率技术可用于获取预后信息，从而用于该病的治疗规划。然而，约15%的假阴性率表明，在外阴和阴道黑色素瘤的管理中使用前哨淋巴结活检之前，有必要仔细考虑。
