Papanas N, Maltezos E
Outpatient Department of Diabetes, Obesity and Metabolism at the Second Department of Internal Medicine, Democritus University of Thrace, Greece.
Int J Low Extrem Wounds. 2007 Mar;6(1):37-53. doi: 10.1177/1534734606298416.
Foot ulcers remain a common problem, leading to increased morbidity in patients with diabetes. Despite the progress that has been achieved in revascularization techniques as well as in off-loading to relieve high-pressure areas, diabetic foot wounds remain a clinical challenge. Growth factors are a major technological advance that promised to change the face of wound healing. The most important of growth factors are recombinant human platelet-derived growth factor-BB and granulocyte colony-stimulating factor. The former has been approved by the FDA for the treatment of neuropathic ulcers when there is adequate blood supply. The latter is less demonstrably useful. Advances include methods of delivering growth factors.
足部溃疡仍然是一个常见问题，会导致糖尿病患者的发病率增加。尽管在血管重建技术以及减轻高压区域负荷方面已经取得了进展，但糖尿病足伤口仍然是一个临床挑战。生长因子是一项有望改变伤口愈合面貌的重大技术进步。最重要的生长因子是重组人血小板衍生生长因子-BB和粒细胞集落刺激因子。前者已获美国食品药品监督管理局（FDA）批准，用于治疗有充足血液供应的神经性溃疡。后者的作用则不太明显。进展包括生长因子的递送方法。
