不同Gag CD8 T细胞逃逸突变型猿猴-人类免疫缺陷病毒对猕猴的体内适应性代价
In vivo fitness costs of different Gag CD8 T-cell escape mutant simian-human immunodeficiency viruses for macaques.
作者信息
Loh Liyen, Batten C Jane, Petravic Janka, Davenport Miles P, Kent Stephen J
机构信息
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia.
出版信息
J Virol. 2007 May;81(10):5418-22. doi: 10.1128/JVI.02763-06. Epub 2007 Mar 7.
Abstract
The kinetics of immune escape and reversion depend upon the efficiency of CD8 cytotoxic T lymphocytes (CTL) and the fitness cost of escape mutations. Escape kinetics of three simian immunodeficiency virus Gag CTL epitopes in pigtail macaques were variable; those of KP9 and AF9 were faster than those of KW9. Kinetics of reversion of escape mutant virus to wild type upon passage to naïve major histocompatibility complex-mismatched macaques also varied. Rapid reversion occurred at KP9, gradual biphasic reversion occurred at AF9, and escape mutant KW9 virus failed to revert. The fitness impact of these mutations is KP9 > AF9 > KW9. These data provide insights into the differential utility of CTL in controlling viremia.
摘要
免疫逃逸和回复的动力学取决于CD8细胞毒性T淋巴细胞（CTL）的效率以及逃逸突变的适应性代价。猪尾猕猴中三种猿猴免疫缺陷病毒Gag CTL表位的逃逸动力学各不相同；KP9和AF9的逃逸速度比KW9快。将逃逸突变病毒传给未经感染的主要组织相容性复合体不匹配的猕猴后，其回复为野生型的动力学也有所不同。KP9处发生快速回复，AF9处发生渐进性双相回复，而逃逸突变KW9病毒未能回复。这些突变对适应性的影响为KP9 > AF9 > KW9。这些数据为CTL在控制病毒血症中的不同效用提供了见解。
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