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不同Gag CD8 T细胞逃逸突变型猿猴-人类免疫缺陷病毒对猕猴的体内适应性代价

In vivo fitness costs of different Gag CD8 T-cell escape mutant simian-human immunodeficiency viruses for macaques.

作者信息

Loh Liyen, Batten C Jane, Petravic Janka, Davenport Miles P, Kent Stephen J

机构信息

Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia.

出版信息

J Virol. 2007 May;81(10):5418-22. doi: 10.1128/JVI.02763-06. Epub 2007 Mar 7.

DOI:10.1128/JVI.02763-06
PMID:17344299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1900239/
Abstract

The kinetics of immune escape and reversion depend upon the efficiency of CD8 cytotoxic T lymphocytes (CTL) and the fitness cost of escape mutations. Escape kinetics of three simian immunodeficiency virus Gag CTL epitopes in pigtail macaques were variable; those of KP9 and AF9 were faster than those of KW9. Kinetics of reversion of escape mutant virus to wild type upon passage to naïve major histocompatibility complex-mismatched macaques also varied. Rapid reversion occurred at KP9, gradual biphasic reversion occurred at AF9, and escape mutant KW9 virus failed to revert. The fitness impact of these mutations is KP9 > AF9 > KW9. These data provide insights into the differential utility of CTL in controlling viremia.

摘要

免疫逃逸和回复的动力学取决于CD8细胞毒性T淋巴细胞（CTL）的效率以及逃逸突变的适应性代价。猪尾猕猴中三种猿猴免疫缺陷病毒Gag CTL表位的逃逸动力学各不相同；KP9和AF9的逃逸速度比KW9快。将逃逸突变病毒传给未经感染的主要组织相容性复合体不匹配的猕猴后，其回复为野生型的动力学也有所不同。KP9处发生快速回复，AF9处发生渐进性双相回复，而逃逸突变KW9病毒未能回复。这些突变对适应性的影响为KP9 > AF9 > KW9。这些数据为CTL在控制病毒血症中的不同效用提供了见解。

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本文引用的文献

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Nat Med. 2007 Jan;13(1):46-53. doi: 10.1038/nm1520. Epub 2006 Dec 17.
2
MHC class I allele frequencies in pigtail macaques of diverse origin.不同来源猪尾猕猴的MHC I类等位基因频率。
Immunogenetics. 2006 Dec;58(12):995-1001. doi: 10.1007/s00251-006-0164-8. Epub 2006 Nov 10.
3
Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution.序列多态性的快速逆转主导了早期人类免疫缺陷病毒1型的进化。
J Virol. 2007 Jan;81(1):193-201. doi: 10.1128/JVI.01231-06. Epub 2006 Oct 25.
4
Comparative efficacy of subtype AE simian-human immunodeficiency virus priming and boosting vaccines in pigtail macaques.AE亚型猿猴-人类免疫缺陷病毒初免和加强疫苗在猪尾猕猴中的比较疗效
J Virol. 2007 Jan;81(1):292-300. doi: 10.1128/JVI.01727-06. Epub 2006 Oct 18.
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Tat(28-35)SL8-specific CD8+ T lymphocytes are more effective than Gag(181-189)CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay.在一项功能性体外试验中，Tat(28 - 35)SL8特异性CD8 + T淋巴细胞在抑制猿猴免疫缺陷病毒复制方面比Gag(181 - 189)CM9特异性CD8 + T淋巴细胞更有效。
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6
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J Virol. 2005 Nov;79(21):13239-49. doi: 10.1128/JVI.79.21.13239-13249.2005.
7
Use of molecular beacons for rapid, real-time, quantitative monitoring of cytotoxic T-lymphocyte epitope mutations in simian immunodeficiency virus.利用分子信标对猿猴免疫缺陷病毒中细胞毒性T淋巴细胞表位突变进行快速、实时、定量监测。
J Clin Microbiol. 2005 Sep;43(9):4773-9. doi: 10.1128/JCM.43.9.4773-4779.2005.
8
Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3.经黏膜给药的人猿免疫缺陷病毒DNA和基于鸡痘病毒的重组疫苗，可降低猕猴经阴道接种CCR5嗜性SHIVSF162P3后急性期的病毒复制。
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9
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Trends Microbiol. 2005 Jun;13(6):243-6. doi: 10.1016/j.tim.2005.03.011.
10
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