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一种四层DOI-PET系统(jPET-D4)的设计与初步评估

Design and inital evaluation of a 4-layer DOI-PET system: the jPET-D4.

作者信息

Yoshida Eiji, Yamaya Taiga, Watanabe Mitsuo, Kitamura Keishi, Kobayashi Ayako, Hasegawa Tomoyuki, Obi Takashi, Haneishi Hideaki, Fukushi Masahiro, Murayama Hideo

机构信息

National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

出版信息

Igaku Butsuri. 2006;26(3):131-40.

Abstract

PET scanners are an important component in functional brain imaging devices. Several PET scanners have been developed during the last two decades for brain research studies. We are developing a high-performance brain PET scanner, jPET-D4. This scanner is designed to achieve not only high spatial resolution but also high sensitivity using four-layered depth-of-interaction (DOI) detectors. The scanner has five block detector rings with the ring diameter of 390 mm and each block detector ring consists of 24 DOI detectors. In previous work, we have demonstrated that 3 mm FWHM uniform spatial resolution within the field-of-view could be realized. In this paper, we describe the jPET-D4 system and evaluate its performance. The average energy resolution for 120 DOI detectors is optimized to 16 % +/- 1.0 %. The scatter fraction for this system is 40 % with an energy window of 400-600 keV. The sensitivity for the point source is 102 kcps/MBq (10.2 %) with a 400 keV LLD. Maximum noise equivalent count rate (NECR) is 154 kcps at 11 kBq/ml with a 10 ns coincidence time window. We evaluated scatter fraction and NECR following procedures based on NEMA NU2-1994. These first evaluation measurements indicate the jPET-D4 has good performance.

摘要

正电子发射断层扫描(PET)扫描仪是功能性脑成像设备的重要组成部分。在过去二十年中,已经开发出了几种用于脑研究的PET扫描仪。我们正在开发一种高性能的脑部PET扫描仪,即jPET-D4。该扫描仪旨在使用四层相互作用深度(DOI)探测器,不仅实现高空间分辨率,还实现高灵敏度。该扫描仪有五个块状探测器环,环直径为390毫米,每个块状探测器环由24个DOI探测器组成。在之前的工作中,我们已经证明在视野范围内可以实现3毫米半高宽的均匀空间分辨率。在本文中,我们描述了jPET-D4系统并评估了其性能。120个DOI探测器的平均能量分辨率优化到了16%±1.0%。该系统在400-600 keV能量窗口下的散射分数为40%。在400 keV下限甄别能量(LLD)时,点源的灵敏度为102 kcps/MBq(10.2%)。在10 ns符合时间窗口下,在11 kBq/ml时最大噪声等效计数率(NECR)为154 kcps。我们按照基于NEMA NU2-1994的程序评估了散射分数和NECR。这些首次评估测量表明jPET-D4具有良好的性能。

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