肾脏对反复接触内毒素的反应：对急性肾损伤的影响
Renal response to repeated exposure to endotoxin: implications for acute kidney injury.
作者信息
Nath K A
机构信息
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
出版信息
Kidney Int. 2007 Mar;71(6):477-9. doi: 10.1038/sj.ki.5002150.
PMID:17344894
Abstract
Zager and colleagues demonstrate that endotoxin tolerance is accompanied by an augmented inflammatory response in the kidney, the latter also exhibiting cholesterol-dependent cytoresistance. These novel findings are discussed mainly from the perspective of acute kidney injury and its prevention by preconditioning and the elicitation of cytoprotective pathways.
摘要
扎格及其同事证明，内毒素耐受伴随着肾脏炎症反应增强，后者还表现出胆固醇依赖性细胞抵抗。这些新发现主要从急性肾损伤及其通过预处理和诱导细胞保护途径进行预防的角度进行了讨论。
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