Nath K A
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Kidney Int. 2007 Mar;71(6):477-9. doi: 10.1038/sj.ki.5002150.
Zager and colleagues demonstrate that endotoxin tolerance is accompanied by an augmented inflammatory response in the kidney, the latter also exhibiting cholesterol-dependent cytoresistance. These novel findings are discussed mainly from the perspective of acute kidney injury and its prevention by preconditioning and the elicitation of cytoprotective pathways.
扎格及其同事证明，内毒素耐受伴随着肾脏炎症反应增强，后者还表现出胆固醇依赖性细胞抵抗。这些新发现主要从急性肾损伤及其通过预处理和诱导细胞保护途径进行预防的角度进行了讨论。
