Chen Hui, Xing Bianzhi, Liu Xiuheng, Zhan Bingyan, Zhou Jiangqiao, Zhu Hengcheng, Chen Zhiyuan
Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Jiefang Road 238, Wuhan, 430060, China.
Eur J Pharmacol. 2008 Mar 10;581(3):306-14. doi: 10.1016/j.ejphar.2007.11.050. Epub 2007 Nov 28.
Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that ozone oxidative preconditioning (OzoneOP) attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of the OzoneOP in modulating inflammation and apoptosis after renal ischemia/reperfusion injury. Rats were subjected to 45 min of renal ischemia, with or without treatment with OzoneOP (1 mg/kg). Renal function, inflammation and apoptosis were compared at 24 h after renal injury. OzoneOP improved the renal dysfunction and reduced inflammation and apoptosis after ischemia/reperfusion injury. In conclusion, OzoneOP has potent anti-apoptotic and anti-inflammatory properties. These findings may have major implications in the treatment of human ischemic acute renal failure.
缺血/再灌注损伤在肾脏外科手术或移植领域较为常见，是急性肾衰竭的主要原因。先前的研究表明，臭氧氧化预处理（OzoneOP）可减轻肾脏缺血/再灌注损伤。本研究的目的是探讨OzoneOP在调节肾脏缺血/再灌注损伤后炎症和细胞凋亡中的作用。将大鼠进行45分钟的肾脏缺血处理，分为接受或未接受OzoneOP（1mg/kg）处理两组。在肾脏损伤后24小时比较肾功能、炎症和细胞凋亡情况。OzoneOP改善了缺血/再灌注损伤后的肾功能障碍，减少了炎症和细胞凋亡。总之，OzoneOP具有强大的抗细胞凋亡和抗炎特性。这些发现可能对人类缺血性急性肾衰竭的治疗具有重要意义。
