Wang Zeng-jun, Zhang Wei
Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Zhonghua Nan Ke Xue. 2007 Feb;13(2):168-70.
The epididymal protease inhibitor (Eppin) abounds in human semen and on the surface of human spermatozoa, specifically produced by the testis and epididymis. Recombinant Eppin has effected infertility in the immunized monkey and promises to be an effective vaccine for human immunocontraception. This article reviews the advances in the studies of Eppin gene and protein construction and its molecular mechanism of causing immunologic infertility and regulating PSA hydrolysis of Semenogelin.
附睾蛋白酶抑制剂（Eppin）大量存在于人类精液及人类精子表面，由睾丸和附睾特异性产生。重组Eppin已在免疫后的猴子身上导致不育，有望成为一种有效的人类免疫避孕疫苗。本文综述了Eppin基因和蛋白结构的研究进展及其导致免疫性不育和调节精液凝胶蛋白酶A水解的分子机制。
