O'Rand M G, Widgren E E, Wang Zengjun, Richardson R T
Department of Cell & Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina-27599, USA.
Soc Reprod Fertil Suppl. 2007;63:445-53.
Eppin (epididymal protease inhibitor) is one of several serine protease (or serine protease-like) inhibitors that are encoded by genes on human chromosome 20 and on mouse chromosome 2. Here we review our current knowledge of human and mouse Eppin genes and the Eppin protein in the context of protease inhibitors. Antibodies to Eppin in immunized male monkeys provide an effective and reversible contraceptive and these antibodies may be effective by interfering with Eppin's interaction with semenogelin during ejaculation. We review Eppin-semenogelin interaction and present a working model in the context of the hydrolysis of semenogelin by prostate specific antigen.
附睾蛋白酶抑制剂（Eppin）是由人类20号染色体和小鼠2号染色体上的基因编码的几种丝氨酸蛋白酶（或类丝氨酸蛋白酶）抑制剂之一。在此，我们结合蛋白酶抑制剂来综述目前关于人类和小鼠Eppin基因以及Eppin蛋白的知识。免疫雄性猴子体内产生的抗Eppin抗体可提供一种有效且可逆的避孕方法，这些抗体可能通过在射精过程中干扰Eppin与精液凝块蛋白的相互作用而发挥作用。我们综述了Eppin与精液凝块蛋白的相互作用，并在前列腺特异性抗原水解精液凝块蛋白的背景下提出了一个工作模型。
