非洲的种族间基因分化：冈比亚的HLA I类抗原
Interethnic genetic differentiation in Africa: HLA class I antigens in The Gambia.
作者信息
Allsopp C E, Harding R M, Taylor C, Bunce M, Kwiatkowski D, Anstey N, Brewster D, McMichael A J, Greenwood B M, Hill A V
机构信息
Molecular Immunology Group, University of Oxford, John Radcliffe Hospital, England.
出版信息
Am J Hum Genet. 1992 Feb;50(2):411-21.
Abstract
A total of 752 individuals from The Gambia, west Africa who are representative of the major ethnic groups in the capital, Banjul, were serologically typed for HLA-A, -B, and -C antigens. Although all were typically "African" in their antigenic profiles, some marked frequency differences were found between the ethnic groups. Genetic distance comparisons with several other African populations showed that, although these west African populations clustered closely together, the positions of the various ethnic groups in The Gambia were consistent with historical and linguistic evidence of their affinities with one another and with other African populations. Despite the potential confounding effects both of selection by infectious diseases and of genetic drift caused by local differences in population structure, HLA frequencies appear to be of value in measuring inter- and intraregional population affinities in sub-Saharan Africa.
摘要
对来自西非冈比亚首都班珠尔主要族群的752人进行了HLA - A、- B和 - C抗原的血清学分型。尽管所有个体的抗原谱都具有典型的“非洲”特征，但不同族群之间仍发现了一些显著的频率差异。与其他几个非洲人群的遗传距离比较表明，尽管这些西非人群紧密聚类在一起，但冈比亚不同族群的位置与它们彼此之间以及与其他非洲人群亲缘关系的历史和语言证据一致。尽管存在传染病选择和种群结构局部差异导致的遗传漂变的潜在混杂效应，但HLA频率在衡量撒哈拉以南非洲地区间和地区内的种群亲缘关系方面似乎具有价值。
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