Majoko F M, Nyström L, Munjanja S P, Mason E, Lindmark G
Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe.
Afr J Reprod Health. 2004 Dec;8(3):198-206.
This population-based cohort study was conducted to compare pregnancy complications and outcome among nulliparous, low (1-5) and high (> or = 6) parity women. Women who registered for antenatal care and gave birth in Guru District, Zimbabwe, between January 1995 and June 1998 were classified into groups by parity. The women were compared for baseline characteristics, utilisation of health facilities and occurrence of pregnancy complications such as hypertensive disorders of pregnancy, haemorrhage, pre-term delivery, operative delivery, low birth weight and perinatal death. In estimating risk, primiparous (parity = 1) women were used as referents. Pregnancy records for 10,569 women were analysed. Mean ages of nulliparous and high parity (> or = 6) women were 20.1 and 37.7 years respectively (p < 0.001). Prevalence of anaemia at booking (haemoglobin < or =10.5 g/dl) was reduced in nulliparous compared to multiparous women (11.7% vs 16.8%; p > or = 0.001). Nulliparous women were likely to book early (< or = 20 weeks) for antenatal care, have a higher number of visits (> or = 6) and fewer home births. Nulliparous women had higher risk for low birth weight (RR 1.70; 95% CI 1.36 - 2.13). Compared to low parity women, nulliparous and high parity women had an elevated risk of hypertensive complications RR 1.62 (95% CI 1.37-1.92) and RR 1.64 (95% CI 1.29 - 2.07) respectively. The risk of developing any pregnancy complications was highest in nulliparous women (RR 1.48; 95% 1.31- 1.67). In conclusion, nulliparous women had an increased risk of pregnancy complications. High parity women with no previous complicated pregnancy were at low risk of complications.
这项基于人群的队列研究旨在比较初产妇、低产次(1 - 5次)和高产次(≥6次)妇女的妊娠并发症及结局。1995年1月至1998年6月期间在津巴布韦古鲁区登记进行产前检查并分娩的妇女按产次分组。比较了这些妇女的基线特征、卫生设施利用情况以及妊娠并发症的发生情况,如妊娠高血压疾病、出血、早产、手术分娩、低出生体重和围产期死亡。在评估风险时,以初产妇(产次 = 1)作为对照。分析了10569名妇女的妊娠记录。初产妇和高产次(≥6次)妇女的平均年龄分别为20.1岁和37.7岁(p < 0.001)。与经产妇相比,初产妇在登记时贫血的患病率较低(血红蛋白≤10.5 g/dl,分别为11.7%和16.8%;p≥0.001)。初产妇更有可能早期(≤20周)登记进行产前检查,就诊次数较多(≥6次)且在家分娩较少。初产妇发生低出生体重的风险较高(相对危险度1.70;95%可信区间1.36 - 2.13)。与低产次妇女相比,初产妇和高产次妇女发生高血压并发症的风险分别升高(相对危险度1.62,95%可信区间1.37 - 1.92)和相对危险度1.64(95%可信区间1.29 - 2.07)。初产妇发生任何妊娠并发症的风险最高(相对危险度1.48;95%可信区间1.31 - 1.67)。总之,初产妇发生妊娠并发症的风险增加。既往无复杂妊娠史的高产次妇女并发症风险较低。