撒哈拉以南非洲地区感染艾滋病毒妇女的妊娠高血压：患病率及婴儿结局
Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes.
作者信息
Kilewo C, Natchu U C M, Young A, Donnell D, Brown E, Read J S, Sharma U, Chi B H, Goldenberg R, Hoffman I, Taha T E, Fawzi W W
机构信息
Department of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
出版信息
Afr J Reprod Health. 2009 Dec;13(4):25-36.
Abstract
This analysis was performed to determine the prevalence of hypertension and association of MAP (mean arterial pressure) with birth outcomes among HIV-infected pregnant women not taking antiretrovirals. HIV-infected pregnant women, enrolled into the HPTN024 trial in Tanzania, Malawi and Zambia were followed up at 26-30, 36 weeks, and delivery. The prevalence of hypertension was <1% at both 20-24 weeks and 26-30 weeks and 1.7% by 36 weeks. A 5 mm Hg elevation in MAP increased the risk of stillbirth at 20-24 weeks by 29% (p = 0.001), 32% (p = 0.001) at 26-30 weeks and of low birth weight (LBW) at 36 weeks by 26% (p = 0.001). MAP was not associated with stillbirth at 36 weeks, LBW prior to 36 weeks, preterm birth, neonatal mortality or the risk of maternal to child transmission (MTCT) of HIV.
摘要
进行此项分析是为了确定未接受抗逆转录病毒治疗的感染艾滋病毒的孕妇中高血压的患病率以及平均动脉压（MAP）与分娩结局之间的关联。参与坦桑尼亚、马拉维和赞比亚的HPTN024试验的感染艾滋病毒的孕妇在孕26 - 30周、36周时以及分娩时接受随访。孕20 - 24周和26 - 30周时高血压患病率均<1%，到36周时为1.7%。MAP升高5 mmHg使孕20 - 24周时死产风险增加29%（p = 0.001），孕26 - 30周时增加32%（p = 0.001），36周时低出生体重（LBW）风险增加26%（p = 0.001）。MAP与36周时的死产、36周前的低出生体重、早产、新生儿死亡率或艾滋病毒母婴传播（MTCT）风险无关。
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