处于血液学缓解期的多发性骨髓瘤患者的肝脏和肾脏浆细胞病变

Hepatic and renal plasma cell lesions in a patient with multiple myeloma in hematological remission.

作者信息

Galani Zacharoula, Viniou Nora, Kyrtsonis Marie-Christine, Sachanas Sotirios, Antoniou Telemachos, Dimopoulou Maria N, Vassilakopoulos Theodoros P, Korkolopoulou Penelope, Nakopoulou Lydia, Patsouris Efstratios, Pangalis Gerassimos A

机构信息

First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.

出版信息

Anticancer Res. 2007 Jan-Feb;27(1B):571-4.

PMID:17348443

Abstract

Plasma cell myeloma is characterized by plasma cell infiltrations, the presence of paraprotein and mostly skeletal destruction with osteolytic lesions. Liver or kidney infiltration has been described in patients with end stage multiple myeloma (MM), while the features of this malignant dissemination is not clearly understood. An atypical form of MM relapse is presented in a patient being in bone marrow remission, with simultaneous lesions in liver, kidney and suspicion of brain involvement. This case is an interesting model of refractory MM extraosseous involvement, that a clinician should be aware of when carrying out differential diagnosis.

摘要

浆细胞骨髓瘤的特征是浆细胞浸润、副蛋白的存在以及主要伴有溶骨性病变的骨骼破坏。已有文献报道终末期多发性骨髓瘤（MM）患者存在肝脏或肾脏浸润，但这种恶性播散的特征尚不清楚。一名处于骨髓缓解期的患者出现了非典型的MM复发形式，同时伴有肝脏、肾脏病变以及疑似脑部受累。该病例是难治性MM骨外受累的一个有趣模型，临床医生在进行鉴别诊断时应予以关注。