Chen Li, Huang Zhiqiang, Wang Qingmin, Shang Jian, Huang Runqiu, Bi Fuchun
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
J Agric Food Chem. 2007 Apr 4;55(7):2659-63. doi: 10.1021/jf063564g. Epub 2007 Mar 10.
New propesticides with two effects of both benzoylphenylureas and carbamates were designed and synthesized by the key intermediate N-chlorosulfenyl-N-methylcarbamate, which was prepared for the first time. These benzoylphenylurea-S-carbamates were identified by 1H NMR spectroscopy and elemental analyses. The bioactivities of the new compounds were evaluated. These benzoylphenylurea-S-carbamates exhibited excellent larvicidal activities against Oriental armyworm, some of which were good as compared to the parent benzoylphenylureas. Toxicity assays indicated that these benzoylphenylurea-S-carbamates had knockdown activities of carbamates at higher concentrations and insect growth regulator activities of benzoylphenylureas at lower concentrations. We found that the title compounds exhibited good systemic larvicidal activities against Oriental armyworm, which were especially advantageous when combating sucking pests. Some of these title compounds can kill aphids and mosquitoes as well.
通过首次制备的关键中间体N-氯硫酰基-N-甲基氨基甲酸酯，设计并合成了兼具苯甲酰基苯基脲和氨基甲酸酯两种作用的新型农药。这些苯甲酰基苯基脲-S-氨基甲酸酯通过1H NMR光谱和元素分析进行了鉴定。对新化合物的生物活性进行了评估。这些苯甲酰基苯基脲-S-氨基甲酸酯对东方粘虫表现出优异的杀幼虫活性，其中一些与母体苯甲酰基苯基脲相比效果良好。毒性试验表明，这些苯甲酰基苯基脲-S-氨基甲酸酯在较高浓度下具有氨基甲酸酯的击倒活性，在较低浓度下具有苯甲酰基苯基脲的昆虫生长调节剂活性。我们发现，标题化合物对东方粘虫表现出良好的内吸性杀幼虫活性，这在防治刺吸式害虫时尤为有利。其中一些标题化合物还能杀死蚜虫和蚊子。
