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合成、杀幼虫活性及含肟醚和肟酯基团的新型苯甲酰基苯基脲的 SAR 研究。

Synthesis, larvicidal activity, and SAR studies of new benzoylphenylureas containing oxime ether and oxime ester group.

机构信息

State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.

出版信息

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4693-9. doi: 10.1016/j.bmcl.2010.04.144. Epub 2010 May 5.

Abstract

A series of new structural benzoylphenylureas (BPUs) containing oxime ether and oxime ester group were designed and synthesized. The larvicidal activities against Oriental armyworm and mosquito of these benzoylphenylureas were evaluated and the result of bioassay displayed specific structure-activity relationship (SAR). Most of the compounds exhibited excellent larvicidal activities against Oriental armyworm and mosquito. Interestingly, some compounds showed different structure-activity relationship towards diamondback moth, beet armyworm, and corn borer although three tested insects all belong to the same insect order.

摘要

设计并合成了一系列含有肟醚和肟酯基团的新型结构苯甲酰基苯脲(BPUs)。评估了这些苯甲酰基苯脲对东方粘虫和蚊子的杀虫活性,生物测定结果显示出特定的构效关系(SAR)。大多数化合物对东方粘虫和蚊子表现出优异的杀虫活性。有趣的是,尽管三种测试昆虫都属于同一昆虫目,但有些化合物对小菜蛾、甜菜夜蛾和玉米螟表现出不同的构效关系。

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