Jweied Eias, deTombe Pieter, Buttrick Peter M
Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, USA.
J Mol Cell Cardiol. 2007 Apr;42(4):722-6. doi: 10.1016/j.yjmcc.2007.02.002. Epub 2007 Feb 9.
There has been increasing enthusiasm for biomedical research that focuses directly on human pathophysiology, in part fueled by the recent NIH roadmap initiative. While this approach has considerable merit, a myopic and primary focus on human disease and on human tissue introduces a plethora of research risks and concerns that could potentially complicate data interpretation and retard scientific progress. While some of these issues are generic when one extrapolates from animal models to the human circumstance, others are more specific to the cardiovascular system in general and to the study of cardiocyte biology in particular. This brief review will highlight some of these.
直接关注人类病理生理学的生物医学研究越来越受到关注，这在一定程度上受到美国国立卫生研究院（NIH）近期路线图计划的推动。虽然这种方法有相当大的优点，但对人类疾病和人体组织的短视和主要关注带来了大量研究风险和问题，这些可能会使数据解释复杂化并阻碍科学进展。虽然其中一些问题在从动物模型推断到人类情况时是普遍存在的，但其他问题在一般心血管系统尤其是心肌细胞生物学研究中更为具体。本简要综述将重点介绍其中一些问题。
