Dahl Alv A, Bremnes Roy, Dahl Olav, Klepp Olbjørn, Wist Erik, Fosså Sophie D
The Cancer Clinic, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway.
Eur Urol. 2007 Nov;52(5):1438-47. doi: 10.1016/j.eururo.2007.02.046. Epub 2007 Mar 1.
This study explores sexual function in a large unselected sample of Norwegian testicular cancer survivors (TCSs) by comparing the results with population data.
The study included 1084 TCSs aged 20-59 yr with mean follow-up time of 11.1 (range: 5-21) yr. They provided information about their medical, social, lifestyle, and familial situations on a questionnaire that included the Brief Male Sexual Function Inventory (BSFI). Outcome measures were mean BSFI domain scores and BSFI-based prevalence rates of sexual problems. The BSFI findings of an age-adjusted random sample of the Norwegian male population (N=929) constituted normative data (NORM). Descriptive statistics and logistic regression analyses were applied, and a significance level of <0.01 was applied.
Compared with NORM, TCSs had significantly worse scores on ejaculatory and sexual problems in both young (20-39 yr) and middle-aged (40-59 yr) groups. In the young group, sexual satisfaction was significantly better in TCSs versus NORM. Overall sexual problems were expressed by 38.8% of the TCSs versus 35.5% in NORM. In multivariate analyses, overall sexual problems in TCSs were significantly associated with increasing age, lack of a partner, and a higher anxiety score, while ejaculation problems showed significant association with lack of a partner, and a trend for chemotherapy and neurotoxic side effects (p=0.02).
Compared with NORM, ejaculatory function was compromised in TCSs. Overall sexual problems in TCSs were associated with factors also observed in NORM. Better sexual satisfaction in young TCSs compared with NORM should be noted.
本研究通过将结果与总体数据进行比较，在挪威未经过挑选的大量睾丸癌幸存者（TCS）样本中探究性功能情况。
该研究纳入了1084名年龄在20 - 59岁的TCS，平均随访时间为11.1年（范围：5 - 21年）。他们通过一份包含简短男性性功能量表（BSFI）的问卷提供了有关其医疗、社会、生活方式和家庭状况的信息。结果指标为BSFI各领域平均分以及基于BSFI的性功能问题患病率。挪威男性人群年龄调整随机样本（N = 929）的BSFI结果构成了规范数据（NORM）。应用了描述性统计和逻辑回归分析，显著性水平设定为<0.01。
与NORM相比，年轻组（20 - 39岁）和中年组（40 - 59岁）的TCS在射精和性功能问题方面得分显著更低。在年轻组中，TCS的性满意度显著高于NORM。38.8%的TCS表示存在总体性功能问题，而NORM中这一比例为35.5%。在多变量分析中，TCS的总体性功能问题与年龄增长、缺乏伴侣以及焦虑得分较高显著相关，而射精问题与缺乏伴侣显著相关，并且与化疗及神经毒性副作用存在一定趋势相关性（p = 0.02）。
与NORM相比，TCS的射精功能受损。TCS的总体性功能问题与在NORM中也观察到的因素相关。应注意到年轻TCS的性满意度高于NORM。
