Bravo Francisco G, Gotuzzo Eduardo
Instituto de Medicina Tropical Alexander von Humboldt, Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Hospital Nacional Cayetano Heredia, Lima 31, Peru.
Clin Dermatol. 2007 Mar-Apr;25(2):173-80. doi: 10.1016/j.clindermatol.2006.05.005.
Cutaneous tuberculosis continues to be one of the most elusive and more difficult diagnoses to make for dermatologists practicing in developing countries. Not only because they have to consider a wider differential diagnosis (leishmaniasis, leprosy, actinomycosis, deep fungal infections, etc) but also because of the difficulty in obtaining a microbiological confirmation. Despite all the advances in microbiology, including sophisticated techniques such as polymerase chain reaction, the sensitivity of new methods are no better than the gold standard, that is, the isolation of Mycobacterium tuberculosum in culture. Even now, in the 21st century, we rely on methods as old as the intradermal reaction purified protein derivative (PPD) standard test and therapeutic trials, as diagnostic tools. In this situation, it is important to recognize the many clinical faces of cutaneous tuberculosis to prevent missed or delayed diagnoses.
皮肤结核仍然是发展中国家皮肤科医生最难捉摸、最难做出的诊断之一。这不仅是因为他们必须考虑更广泛的鉴别诊断(利什曼病、麻风病、放线菌病、深部真菌感染等),还因为难以获得微生物学确诊。尽管微生物学取得了所有进展,包括聚合酶链反应等复杂技术,但新方法的敏感性并不比金标准更好,即培养中结核分枝杆菌的分离。即使在21世纪,我们仍依赖像皮内反应纯化蛋白衍生物(PPD)标准试验和治疗性试验这样古老的方法作为诊断工具。在这种情况下,认识到皮肤结核的多种临床表象对于防止漏诊或延误诊断很重要。