Davis K, Marsh J W, Gerondal M, Bailey M R, Le Guen B
Radiation Protection Division, Health Protection Agency (HPA), Chilton, Didcot, Oxon OX11 0RQ, UK.
Health Phys. 2007 Apr;92(4):332-44. doi: 10.1097/01.HP.0000250618.97979.35.
Intakes and doses are assessed for seven workers who accidentally inhaled particles containing Co in the same incident. Comprehensive whole body data to 15 y, and some early urine and fecal data, are available for each individual. The biokinetic and dosimetric models currently recommended by ICRP have been used to assess these cases. It was not possible to obtain good fits to the data using the ICRP models with their default parameter values. However, good fits to all the measurement data were obtained by varying parameter values following a procedure similar to that recommended in recently developed guidelines for assessment of internal doses from monitoring data. It was found that retention in the lungs was much longer than predicted by the ICRP Human Respiratory Tract Model, and so for each case it was necessary to reduce the particle transport clearance of material from the deep lungs. This reduction in lung clearance rates, and the use of specific AMAD values, were the dominating factors in changing assessed doses from those calculated using ICRP default values.
对在同一事故中意外吸入含钴颗粒的7名工人的摄入量和剂量进行了评估。可获得每名工人长达15年的全面全身数据以及一些早期尿液和粪便数据。采用了国际辐射防护委员会（ICRP）目前推荐的生物动力学和剂量学模型来评估这些案例。使用具有默认参数值的ICRP模型无法很好地拟合数据。然而，通过遵循与最近制定的监测数据内照射剂量评估指南中推荐的程序类似的方法改变参数值，获得了与所有测量数据的良好拟合。结果发现，肺部滞留时间比ICRP人类呼吸道模型预测的要长得多，因此对于每个案例，都有必要降低深部肺部物质的颗粒传输清除率。肺部清除率的这种降低以及特定空气动力学等效直径（AMAD）值的使用，是改变评估剂量（与使用ICRP默认值计算的剂量相比）的主要因素。
