外侧杏仁核中不同恐惧记忆的突触特异性再巩固
Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala.
作者信息
Doyère Valérie, Debiec Jacek, Monfils Marie-H, Schafe Glenn E, LeDoux Joseph E
机构信息
Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication (NAMC), Centre National de la Recherche Scientifique (CNRS), UMR8620, Université Paris-Sud, 91405 Orsay, France.
出版信息
Nat Neurosci. 2007 Apr;10(4):414-6. doi: 10.1038/nn1871. Epub 2007 Mar 11.
When reactivated, memories enter a labile, protein synthesis-dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses.
当记忆被重新激活时，会进入一种不稳定的、依赖蛋白质合成的状态，这一过程被称为重新巩固。在此，我们在大鼠身上发现，恐惧记忆的提取会在杏仁核外侧产生一种对重新激活的记忆具有选择性的突触增强，并且重新巩固的破坏与杏仁核外侧突触增强的减少相关。因此，提取和重新巩固都通过选择性靶向突触处的突触可塑性来改变记忆。
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