Kudiakov T I, Sarychev N Iu, Kamenskiĭ A A
Izv Akad Nauk Ser Biol. 2007 Jan-Feb(1):51-7.
The behavior of mice of two inbred strains (C57BL/6J and CBA) and their F1 hybrids was evaluated in the open field test after intraperitoneal administration of 3-methylindole (skatole) disrupting epithelium of the main olfactory system. High motor and exploratory activities and emotional sensitivity was observed in intact C57BL/6J mice compared to CBA mice and their hybrids. Anosmia induced by intraperitoneal administration of skatole changed the behavior of C57BL/6J and CBA mice. The direction of the observed changes in the orientation and exploratory behavior of anosmic animals was different. Anosmia decreased motor and exploratory activities in C57BL/6J mice and increase them in CBA mice. Intact hybrid mice demonstrated the predominance of the CBA genotype in the orientation and exploratory activity in the test used. Anosmia in hybrid animals had no significant effect on the orientation and exploratory behavior.
在腹腔注射破坏主要嗅觉系统上皮的3-甲基吲哚（粪臭素）后，对两个近交系小鼠（C57BL/6J和CBA）及其F1杂种小鼠进行旷场试验，评估其行为。与CBA小鼠及其杂种小鼠相比，完整的C57BL/6J小鼠表现出较高的运动和探索活动以及情绪敏感性。腹腔注射粪臭素诱导的嗅觉缺失改变了C57BL/6J和CBA小鼠的行为。嗅觉缺失动物在定向和探索行为中观察到的变化方向不同。嗅觉缺失使C57BL/6J小鼠的运动和探索活动减少，而使CBA小鼠的运动和探索活动增加。完整的杂种小鼠在所用试验的定向和探索活动中表现出CBA基因型的优势。杂种动物的嗅觉缺失对定向和探索行为没有显著影响。
