Bacalo A, Kivity S, Heno N, Greif Z, Greif J, Topilsky M
Institute of Pulmonary and Allergic Disease, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Chest. 1992 Feb;101(2):362-5. doi: 10.1378/chest.101.2.362.
Pulmonary function tests were performed at rest and following blood transfusion on 17 patients with thalassemia major. At rest, diffusion capacity was significantly reduced (mean of 57 percent), and forced vital capacity was mildly reduced (mean of 85 percent). In two of the patients, arterial oxygen tension was low. Other pulmonary function results were in the normal range. Following blood transfusion, a significant drop was seen in arterial oxygen tension (PaO2 of 22 mm Hg) and in forced vital capacity (FVC) of 32 percent. These changes were dramatic and require further explanation.
对17例重型地中海贫血患者在静息状态下以及输血后进行了肺功能测试。静息时，弥散能力显著降低（平均为57%），用力肺活量轻度降低（平均为85%）。其中2例患者动脉血氧分压较低。其他肺功能结果在正常范围内。输血后，动脉血氧分压（PaO2下降22 mmHg）和用力肺活量（FVC）下降32%，出现了显著下降。这些变化很显著，需要进一步解释。
