Fung K P, Chow O K, So S Y, Yuen P M
Department of Pediatrics, National University of Singapore.
J Pediatr. 1987 Oct;111(4):534-7. doi: 10.1016/s0022-3476(87)80113-0.
Pulmonary function tests were evaluated in 28 Chinese patients with beta-thalassemia major receiving regular transfusions and desferoxamine, and in 34 height-matched normal Chinese children. Comparison of lung function using analysis of covariance with reference to standing height showed that patients with thalassemia had a proportional decrease in forced vital capacity and forced expiratory flow volume in 1 second, whereas their expiratory flow rates, residual volume, and total lung capacity were comparable to those in normal children. The single-breath carbon monoxide diffusion capacity was normal. Our findings suggest that children with thalassemia major have mild restrictive lung disease. The previous controversy regarding the presence of restrictive or obstructive lung disease in patients with thalassemia may be related to the use of inappropriate control values.
对28名接受定期输血和去铁胺治疗的中国重型β地中海贫血患者以及34名身高匹配的正常中国儿童进行了肺功能测试。采用协方差分析并参照身高对肺功能进行比较，结果显示地中海贫血患者的用力肺活量和1秒用力呼气容积呈比例下降，而他们的呼气流量率、残气量和肺总量与正常儿童相当。单次呼吸一氧化碳弥散量正常。我们的研究结果表明，重型地中海贫血儿童患有轻度限制性肺病。先前关于地中海贫血患者存在限制性或阻塞性肺病的争议可能与使用不适当的对照值有关。
