Dosman Cara F, Brian Jessica A, Drmic Irene E, Senthilselvan Ambikaipakan, Harford Mary M, Smith Ryan W, Sharieff Waseem, Zlotkin Stanley H, Moldofsky Harvey, Roberts S Wendy
Developmental-Behavioral Pediatrics, Glenrose Rehabilitation Hospital, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Pediatr Neurol. 2007 Mar;36(3):152-8. doi: 10.1016/j.pediatrneurol.2006.11.004.
To determine if there is a relationship between low serum ferritin and sleep disturbance in children with autism spectrum disorder, an 8-week open-label treatment trial with oral iron supplementation was conducted as a pilot study. At baseline and posttreatment visits, parents completed a Sleep Disturbance Scale for Children and a Food Record. Blood samples were obtained. Thirty-three children completed the study. Seventy-seven percent had restless sleep at baseline, which improved significantly with iron therapy, suggesting a relationship between sleep disturbance and iron deficiency in children with autism spectrum disorder. Sixty-nine percent of preschoolers and 35% of school-aged children had insufficient dietary iron intake. Mean ferritin increased significantly (16 microg/L to 29 microg/L), as did mean corpuscular volume and hemoglobin, suggesting that low ferritin in this patient group resulted from insufficient iron intake. Similar prevalence of low ferritin at school age as preschool age indicates that children with autism spectrum disorder require ongoing screening for iron deficiency.
为了确定自闭症谱系障碍儿童血清铁蛋白水平低与睡眠障碍之间是否存在关联，开展了一项为期8周的口服铁补充剂开放标签治疗试验作为初步研究。在基线和治疗后访视时，家长填写了儿童睡眠障碍量表和饮食记录。采集了血样。33名儿童完成了该研究。77%的儿童在基线时存在睡眠不安，铁疗法使其显著改善，这表明自闭症谱系障碍儿童的睡眠障碍与缺铁之间存在关联。69%的学龄前儿童和35%的学龄儿童饮食中铁摄入量不足。平均铁蛋白显著升高（从16微克/升升至29微克/升），平均红细胞体积和血红蛋白也显著升高，这表明该患者组中铁蛋白水平低是由于铁摄入不足所致。学龄儿童与学龄前儿童铁蛋白水平低的患病率相似，这表明自闭症谱系障碍儿童需要持续筛查缺铁情况。
