Ishizaka Nobukazu, Ishizaka Yuko, Toda Ei-Ichi, Nagai Ryozo, Koike Kazuhiko, Hashimoto Hideki, Yamakado Minoru
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7-3-1, Tokyo, Japan.
Diabetes Res Clin Pract. 2007 Oct;78(1):72-6. doi: 10.1016/j.diabres.2007.02.009. Epub 2007 Mar 13.
We found that cigarette smoking increased white blood cell count, and individuals which increased white blood cell count more likely to have metabolic syndrome in Japanese men. We investigated whether similar relationship can be observed also in women. We analyzed the data from 16,383 Japanese women who underwent general health screening. Age-adjusted logistic regression analysis showed that current smoking was positively associated with a highest white blood cell count quartile with an odds ratio of 2.40 (95% CI: 2.16-2.68, P<0.0001). The white blood cell count showed a graded association with metabolic syndrome. On the other hand, the association between current smoking and metabolic syndrome was no longer significant after subdividing the individuals into groups according to the white blood cell quartile. These data collectively suggested that the association between current smoking and metabolic syndrome is heavily confounded by certain factors that increase the circulating white blood cell count in Japanese women, as in men.
我们发现，吸烟会增加白细胞计数，而且在日本男性中，白细胞计数升高的个体更有可能患有代谢综合征。我们调查了在女性中是否也能观察到类似的关系。我们分析了16383名接受一般健康筛查的日本女性的数据。年龄调整后的逻辑回归分析显示，当前吸烟与白细胞计数最高四分位数呈正相关，优势比为2.40（95%置信区间：2.16 - 2.68，P < 0.0001）。白细胞计数与代谢综合征呈分级关联。另一方面，根据白细胞四分位数将个体分组后，当前吸烟与代谢综合征之间的关联不再显著。这些数据共同表明，与男性一样，在日本女性中，当前吸烟与代谢综合征之间的关联受到某些会增加循环白细胞计数的因素的严重混淆。
