a Department of Biochemistry , Georgetown University Medical Center , Washington, D.C. , USA.
b Integrative Health Technologies , San Antonio , Texas , USA.
J Am Coll Nutr. 2017 Sep-Oct;36(7):556-564. doi: 10.1080/07315724.2017.1322545. Epub 2017 Sep 12.
Insulin resistance and advancing age are well-recognized risk factors for metabolic syndrome. Recent reports indicate that fasting glucose levels in non-diabetic patients correlate appropriately with the development of certain elements in metabolic syndrome, which suggest a cause-effect relationship with insulin resistance.
The present investigation assessed whether a significant association exists between chronological age and various elements of metabolic syndrome in this same group of subjects possessing non-diabetic fasting glucose levels.
Baseline data were taken from 288 subjects (age 17-87 years) with fasting glucose levels ≤ 125 mg/dl. Correlations between chronological age and different metabolic parameters were assessed to determine any statistically significant relationships and compare these with previously demonstrated metabolic parameters.
With the exception of systolic blood pressure, the following correlations between age and components of metabolic syndrome were not significant or even significant in the opposite direction compared to those found in the same population using fasting glucose as the independent variable: body weight, body fat, diastolic blood pressure, white blood cell count (WBC)/neutrophil count, and circulating levels of insulin, high-density lipoprotein (HDL) cholesterol, triglycerides, high-sensitivity C-reactive protein (hs-CRP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Although systolic blood pressure still increased, it was to a lesser extent than might be expected.
In the present investigation, a cross-sectional analysis was carried out over a wide age range of subjects. It is noteworthy that fasting glucose levels and the other major elements of metabolic syndrome did not change significantly with advancing age. These results demonstrate that decreasing insulin resistance and fasting glucose levels may be an important way to overcome the adverse effects and perturbations of advancing age-induced consequences of metabolic syndrome.
胰岛素抵抗和年龄增长是代谢综合征的公认危险因素。最近的报告表明，非糖尿病患者的空腹血糖水平与代谢综合征的某些元素的发展密切相关，这表明与胰岛素抵抗存在因果关系。
本研究评估了在具有非糖尿病空腹血糖水平的同一组受试者中，年龄与代谢综合征的各种元素之间是否存在显著相关性。
从空腹血糖水平≤125mg/dl 的 288 名受试者（年龄 17-87 岁）中获取基线数据。评估年龄与不同代谢参数之间的相关性，以确定任何具有统计学意义的关系，并将这些关系与之前证明的代谢参数进行比较。
除收缩压外，年龄与代谢综合征成分之间的以下相关性与使用空腹血糖作为自变量时在同一人群中发现的相关性相比不显著，甚至呈相反方向：体重、体脂肪、舒张压、白细胞计数（WBC）/中性粒细胞计数，以及循环胰岛素、高密度脂蛋白（HDL）胆固醇、甘油三酯、高敏 C 反应蛋白（hs-CRP）、丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）水平。尽管收缩压仍在升高，但升高幅度小于预期。
在本研究中，对具有广泛年龄范围的受试者进行了横断面分析。值得注意的是，空腹血糖水平和代谢综合征的其他主要元素随年龄增长没有明显变化。这些结果表明，降低胰岛素抵抗和空腹血糖水平可能是克服代谢综合征的不良影响和年龄增长引起的代谢紊乱的重要途径。
