Takenaka Miki, Okamoto Yoshiaki, Ikeda Kenji, Hashimoto Ryo, Ueda Takafumi, Kurokawa Nobuo, Takagi Tatsuya, Uejima Etsuko
Dept. of Hospital Pharmacy, Osaka University.
Gan To Kagaku Ryoho. 2007 Mar;34(3):403-7.
There are no reports comparing the efficacy of 3 selective 5-HT(3) receptor antagonists (Granisetron, Ondansetron, and Ramosetron). We designed a prospective study to compare the efficacy of Granisetron, Ondansetron, and Ramosetron. Thirteen patients gave informed consent to participate in the study. We assigned them to groups taking Granisetron, Ondansetron, or Ramosetron before the high-dose chemotherapy. They themselves reported the extent of their nausea and how many times they vomited per day from the first to the sixth day of chemotherapy. We evaluated their report with PLS (Partial Least Squares) and Welch's t-test. From the results of PLS, it was suggested that CDDP contributed the most and Ramosetron the least to the extent of nausea, while Doxorubicin (ADM)/CDDP contributed the most and Ramosetron the least to the frequency of vomiting. Then we compared the antiemetic effect of the agents regarding the types of chemotherapy. It was concluded that Ramosetron might have been the most effective of the three agents in reducing nausea and vomiting, but with no significant difference.
尚无关于三种选择性5-羟色胺(3)受体拮抗剂（格拉司琼、昂丹司琼和雷莫司琼）疗效比较的报告。我们设计了一项前瞻性研究来比较格拉司琼、昂丹司琼和雷莫司琼的疗效。13名患者签署知情同意书参与该研究。在高剂量化疗前，我们将他们分配到服用格拉司琼、昂丹司琼或雷莫司琼的组中。他们自行报告化疗第1天至第6天恶心的程度以及每天呕吐的次数。我们用偏最小二乘法（PLS）和韦尔奇t检验对他们的报告进行评估。从PLS结果来看，顺铂对恶心程度的影响最大，雷莫司琼最小；而阿霉素（ADM）/顺铂对呕吐频率的影响最大，雷莫司琼最小。然后我们比较了这些药物在不同化疗类型中的止吐效果。得出的结论是，雷莫司琼可能是这三种药物中减轻恶心和呕吐最有效的，但差异无统计学意义。
