Park Y, Hatano Y, Sasamoto S, Kato N, Okuyama N, Yamazaki S
Dept. of Thoracic Cardiovascular Surgery, Sakura Hospital, Toho University School of Medicine.
Gan To Kagaku Ryoho. 1997 Mar;24(5):573-7.
The antiemetic efficacy of granisetron in repeated CAF chemotherapy after breast cancer operation was investigated. Twenty-three patients who were treated with repeated CAF chemotherapy after breast cancer operation received drip-infused granisetron (3 mg/body) to prevent nausea and vomiting. Antiemetic efficacy was evaluated by means of the severity of nausea and the frequency of vomiting. The antiemetic efficacy rate of the drug was 74.4%. However, the average rate of antiemetic efficacy was 86.9% on the first through the sixth administration of the chemotherapy (first period). 75.9% on the seventh through the twelfth (second period), 48.4% on the thirteenth through the eighteenth (third period), and 31.8% on the nineteenth through the twenty-fourth (fourth period). There were significant differences in the antiemetic efficacy rate among the first, second and third periods. The antiemetic efficacy of granisetron decreased significantly by repeated CAF chemotherapy.
研究了格拉司琼在乳腺癌术后重复CAF化疗中的止吐疗效。23例乳腺癌术后接受重复CAF化疗的患者接受静脉滴注格拉司琼（3mg/人）以预防恶心和呕吐。通过恶心严重程度和呕吐频率评估止吐疗效。该药物的止吐有效率为74.4%。然而，在化疗的第一次至第六次给药（第一阶段），止吐平均有效率为86.9%；第七次至第十二次（第二阶段）为75.9%；第十三次至第十八次（第三阶段）为48.4%；第十九次至第二十四次（第四阶段）为31.8%。第一、第二和第三阶段的止吐有效率存在显著差异。格拉司琼的止吐疗效因重复CAF化疗而显著降低。
