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扩展的1型链糖鞘脂抗原。岩藻糖基化三糖基-Leb抗原（III4V4VI2Fuc3Lc6）的分离与鉴定

Extended type-1 chain glycosphingolipid antigens. Isolation and characterization of trifucosyl-Leb antigen (III4V4VI2Fuc3Lc6).

作者信息

Stroud M R, Levery S B, Salyan M E, Roberts C E, Hakomori S

机构信息

Biomembrane Institute, Seattle, WA 98119.

出版信息

Eur J Biochem. 1992 Feb 1;203(3):577-86. doi: 10.1111/j.1432-1033.1992.tb16586.x.

DOI:10.1111/j.1432-1033.1992.tb16586.x
PMID:1735443
Abstract

A Lewis-b-active glycosphingolipid containing a repetitive type-1 chain carbohydrate core was isolated from human colonic adenocarcinoma cell line Colo205. This glycosphingolipid was purified by HPLC and preparative high-performance thin-layer chromatography and its structure elucidated by positive-ion fast-atom-bombardment mass spectrometry with collision-induced disassociation, 1H-NMR spectroscopy and methylation analysis. The glycosphingolipid was found to be a trifucosylated derivative of this novel carbohydrate core, having the following structure: [formula; see text].

摘要

从人结肠腺癌细胞系Colo205中分离出一种含有重复1型链碳水化合物核心的Lewis-b活性糖鞘脂。该糖鞘脂通过高效液相色谱法和制备型高效薄层色谱法进行纯化，并通过带碰撞诱导解离的正离子快原子轰击质谱法、1H-核磁共振光谱法和甲基化分析对其结构进行了阐明。发现该糖鞘脂是这种新型碳水化合物核心的三岩藻糖基化衍生物，具有以下结构：[分子式；见正文]。

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