Passmore C A, Sherington J, Stegemann M R
Pfizer Animal Health, Pfizer Ltd, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
J Small Anim Pract. 2007 Mar;48(3):139-44. doi: 10.1111/j.1748-5827.2006.00231.x.
To determine the efficacy and safety of cefovecin (Convenia); Pfizer Animal Health) in the treatment of urinary tract infections in dogs.
A multi-centre, blinded, randomised study was conducted in 129 dogs with urinary tract infections. Cephalexin (Rilexine) administered twice daily at 15 mg/kg bodyweight orally for 14 days was compared with a single, subcutaneous injection of cefovecin (Convenia) in dogs. The primary efficacy parameter assessed was bacterial elimination of the pretreatment uropathogen.
One hundred and twenty-nine dogs were included in efficacy assessments. Escherichia coli was eliminated in 90.5 per cent of cefovecin-treated dogs compared with 52.9 per cent of cephalexin-treated dogs (P=0.0004). Overall cure rates for dogs with Escherichia coli infections were 79.1 per cent for cefovecin and 36.4 per cent for cephalexin-treated dogs (P=0.0003). There were no suspected adverse drug reactions attributed to treatment with cefovecin or cephalexin.
Cefovecin was shown to be an effective and safe treatment for urinary tract infections.
确定头孢维星（康卫宁；辉瑞动物保健公司）治疗犬尿路感染的有效性和安全性。
对129只患有尿路感染的犬进行了一项多中心、双盲、随机研究。将头孢氨苄（力可信）以15mg/kg体重口服，每日两次，连用14天，与给犬单次皮下注射头孢维星（康卫宁）进行比较。评估的主要疗效参数是治疗前尿路病原体的细菌清除情况。
129只犬纳入疗效评估。头孢维星治疗的犬中90.5%的大肠杆菌被清除，而头孢氨苄治疗的犬中这一比例为52.9%（P=0.0004）。大肠杆菌感染犬的总体治愈率，头孢维星治疗组为79.1%，头孢氨苄治疗组为36.4%（P=0.0003）。未发现因头孢维星或头孢氨苄治疗引起的疑似药物不良反应。
头孢维星被证明是治疗犬尿路感染的一种有效且安全的药物。
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