头孢维星（康卫宁）治疗犬尿路感染的有效性和安全性。
Efficacy and safety of cefovecin (Convenia) for the treatment of urinary tract infections in dogs.
作者信息
Passmore C A, Sherington J, Stegemann M R
机构信息
Pfizer Animal Health, Pfizer Ltd, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
出版信息
J Small Anim Pract. 2007 Mar;48(3):139-44. doi: 10.1111/j.1748-5827.2006.00231.x.
OBJECTIVES
To determine the efficacy and safety of cefovecin (Convenia); Pfizer Animal Health) in the treatment of urinary tract infections in dogs.
METHODS
A multi-centre, blinded, randomised study was conducted in 129 dogs with urinary tract infections. Cephalexin (Rilexine) administered twice daily at 15 mg/kg bodyweight orally for 14 days was compared with a single, subcutaneous injection of cefovecin (Convenia) in dogs. The primary efficacy parameter assessed was bacterial elimination of the pretreatment uropathogen.
RESULTS
One hundred and twenty-nine dogs were included in efficacy assessments. Escherichia coli was eliminated in 90.5 per cent of cefovecin-treated dogs compared with 52.9 per cent of cephalexin-treated dogs (P=0.0004). Overall cure rates for dogs with Escherichia coli infections were 79.1 per cent for cefovecin and 36.4 per cent for cephalexin-treated dogs (P=0.0003). There were no suspected adverse drug reactions attributed to treatment with cefovecin or cephalexin.
CLINICAL SIGNIFICANCE
Cefovecin was shown to be an effective and safe treatment for urinary tract infections.
目的
确定头孢维星（康卫宁；辉瑞动物保健公司）治疗犬尿路感染的有效性和安全性。
方法
对129只患有尿路感染的犬进行了一项多中心、双盲、随机研究。将头孢氨苄（力可信）以15mg/kg体重口服，每日两次，连用14天，与给犬单次皮下注射头孢维星（康卫宁）进行比较。评估的主要疗效参数是治疗前尿路病原体的细菌清除情况。
结果
129只犬纳入疗效评估。头孢维星治疗的犬中90.5%的大肠杆菌被清除，而头孢氨苄治疗的犬中这一比例为52.9%（P=0.0004）。大肠杆菌感染犬的总体治愈率，头孢维星治疗组为79.1%，头孢氨苄治疗组为36.4%（P=0.0003）。未发现因头孢维星或头孢氨苄治疗引起的疑似药物不良反应。
临床意义
头孢维星被证明是治疗犬尿路感染的一种有效且安全的药物。
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