Beloni S N, Silva-Costa R, Machado B H, Salgado H C
Department of Physiology, School of Medicine, University of São Paulo, Ribeirão Prêto, Brazil.
Hypertension. 1992 Feb;19(2 Suppl):II116-20. doi: 10.1161/01.hyp.19.2_suppl.ii116.
We investigated in conscious Wistar-Kyoto rats the effect of chemical renal medullectomy on the responses of mean arterial pressure, arterial pressure lability, and heart rate to sinoaortic deafferentation (SAD). Chemical medullectomy was obtained by the intravenous administration of 2-bromoethylamine hydrobromide (2-BEA) 2-3 weeks before SAD or sham SAD. Chemically medullectomized rats were compared with control rats treated with saline. In control rats, the increase in mean arterial pressure elicited by SAD was not significantly greater than that produced by sham SAD. In medullectomized rats, SAD significantly increased mean arterial pressure compared with sham SAD. No direct relation was observed between the response of mean arterial pressure to SAD and the grade (1, 2, or 3) of lesion of the renal papilla. In control rats, SAD increased significantly arterial pressure lability. Chemical medullectomy did not affect basal lability or the increased lability after SAD. No direct relation was observed between increased arterial pressure lability due to SAD and the grade of lesion of the renal papilla. SAD produced a conspicuous tachycardia in control rats. Chemical medullectomy did not affect basal heart rate or the tachycardia produced by SAD. No direct relation was observed between the extent of this tachycardia and the grade of lesion of the renal papilla. These data indicate that lesions of the renal papilla lead to a significant increase in mean arterial pressure after SAD, without affecting basal pressure or heart rate. In addition, SAD per se did not increase significantly the mean arterial pressure in control rats.(ABSTRACT TRUNCATED AT 250 WORDS)
我们在清醒的Wistar-Kyoto大鼠中研究了化学性肾髓质切除对平均动脉压、动脉压变异性以及心率对去窦主动脉神经支配（SAD）反应的影响。在进行SAD或假手术SAD前2 - 3周，通过静脉注射氢溴酸2 - 溴乙胺（2 - BEA）实现化学性肾髓质切除。将化学性肾髓质切除的大鼠与用生理盐水处理的对照大鼠进行比较。在对照大鼠中，SAD引起的平均动脉压升高并不显著高于假手术SAD所产生的升高。在肾髓质切除的大鼠中，与假手术SAD相比，SAD显著升高了平均动脉压。未观察到平均动脉压对SAD的反应与肾乳头损伤程度（1、2或3级）之间存在直接关系。在对照大鼠中，SAD显著增加了动脉压变异性。化学性肾髓质切除不影响基础变异性或SAD后升高的变异性。未观察到因SAD导致的动脉压变异性增加与肾乳头损伤程度之间存在直接关系。SAD在对照大鼠中引起明显的心动过速。化学性肾髓质切除不影响基础心率或SAD所产生的心动过速。未观察到这种心动过速的程度与肾乳头损伤程度之间存在直接关系。这些数据表明，肾乳头损伤导致SAD后平均动脉压显著升高，而不影响基础血压或心率。此外，SAD本身在对照大鼠中并未显著增加平均动脉压。（摘要截短至250字）
