Li M, Birchall I, Kincaid-Smith P S, Whitworth J A
Department of Medicine, St George Hospital, University of New South Wales, Australia.
J Hypertens. 1992 Oct;10(10):1129-36. doi: 10.1097/00004872-199210000-00004.
The mechanism of hypertension induced by adrenocorticotrophin (ACTH) remains unclear. The antihypertensive renomedullary lipids are vasodilators and it has been proposed that a deficiency of these lipids may contribute to the hypertension produced by destruction of the renal papilla. The aim of the present work was to study ACTH hypertension in both control and chemically renomedullectomized rats.
Renomedullectomy was produced by single intraperitoneal injection of 2-bromoethylamine (BEA) at 400 mg/kg.
BEA-treated rats all developed increases in water intake and urine volume, with loss of papillae and medullary and cortical fibrosis. There was a significant correlation between papillary ablation and systolic blood pressure (SBP). SBP in renomedullectomized rats was higher after ACTH than sham injection, and higher than after ACTH injection in intact rats.
Chemical renomedullectomy with BEA did not block or attenuate the onset or magnitude of ACTH hypertension in the rat.
促肾上腺皮质激素（ACTH）诱发高血压的机制尚不清楚。具有降压作用的肾髓质脂质是血管舒张剂，有人提出这些脂质的缺乏可能与肾乳头破坏所导致的高血压有关。本研究的目的是在对照大鼠和化学性肾髓质切除大鼠中研究ACTH高血压。
通过腹腔注射400mg/kg的2-溴乙胺（BEA）进行肾髓质切除。
接受BEA治疗的大鼠均出现水摄入量和尿量增加，伴有乳头缺失以及髓质和皮质纤维化。乳头切除与收缩压（SBP）之间存在显著相关性。肾髓质切除大鼠在接受ACTH注射后的SBP高于假注射后，且高于完整大鼠接受ACTH注射后的SBP。
用BEA进行化学性肾髓质切除并未阻止或减轻大鼠ACTH高血压的发生或严重程度。
