Li Shao-Lin, Zhang Xue-Lin, Han Hui-Xia, Chen Bin
Diagnostic Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2007 Feb;27(2):201-4.
To study the imaging features of primary bone of the lymphoma PLB on X-ray, CT and magnetic resonance imaging (MRI).
The data of 8 patients (6 males and 3 females, aged 9-60 years with a median age of 26.5 years) with pathologically confirmed PLB were retrospectively reviewed. Plain radiographs were obtained in all the 8 cases, CT scans performed in 5 and MRI examinations in 7. Four patients underwent X-ray, CT and MRI, two underwent CT and MRI, and one underwent X-ray and MRI. Surgical resection was performed in 7 cases and biopsy done in 2, and routine histopathological examination and immunohistochemistry were performed for all patients.
The site of PLB focus was found in the pelvic bone in 4 cases, right frontal bone in 1 case, proximal femoral bone in 1 case, occipital clivus in 2 cases, and vertebral column in 1 case. Plain X-ray revealed in 4 cases roughly normal shape of the involved bone with stippled interior bone structure destruction; the other 4 cases presented with slight or moderate bone expansion with obvious signs of osteolysis. CT scans displayed areas of different sizes of osteolytic cortical and marrow cavity destruction with large soft tissue masses around the lesion. MRI found heterogeneous iso- to hyperintense signals in the lesions in the bone and soft-tissue masses on T2-weighted images but homogeneous isointense signals on T2-weighted images. The tumors were obviously enhanced after contrast-enhanced scans on CT and MRI. Histological examination identified B-cell lymphoma in 5 cases and T-cell lymphoma in 4 cases.
PBL is characterized in imaging examinations by basically normal shape of the involved bones with possible bone expansion, obvious stippled osteolytic destruction, large soft-tissue mass around the lesion and obvious enhancement after contrast-enhanced scans.
研究原发性骨淋巴瘤（PLB）在X线、CT及磁共振成像（MRI）上的影像特征。
回顾性分析8例经病理证实的PLB患者（男6例，女2例，年龄9 - 60岁，中位年龄26.5岁）的资料。8例均行X线平片检查，5例行CT扫描，7例行MRI检查。4例患者接受了X线、CT及MRI检查，2例接受了CT及MRI检查，1例接受了X线及MRI检查。7例行手术切除，2例行活检，所有患者均进行常规组织病理学检查及免疫组化检查。
PLB病灶位于骨盆4例，右侧额骨1例，股骨近端1例，枕骨斜坡2例，脊柱1例。X线平片显示4例受累骨外形大致正常，内部骨结构呈斑点状破坏；另4例表现为轻度或中度骨质膨胀，有明显骨质溶解征象。CT扫描显示不同大小的溶骨性皮质和髓腔破坏区，病变周围有较大软组织肿块。MRI显示骨内病变及软组织肿块在T2加权像上呈不均匀等信号至高信号，在T1加权像上呈均匀等信号。CT及MRI增强扫描后肿瘤明显强化。组织学检查确诊为B细胞淋巴瘤5例，T细胞淋巴瘤4例。
PLB在影像学检查中的特征为受累骨外形基本正常，可能有骨质膨胀，有明显斑点状骨质溶解破坏，病变周围有较大软组织肿块，增强扫描后明显强化。
