Kronmann Lisha, Hatfield Chad, Kronmann Karl
Scripps Mercy Hospital/CardinalHealth, San Diego, California 92103, USA.
Crit Care Nurs Q. 2007 Apr-Jun;30(2):154-60. doi: 10.1097/01.CNQ.0000264258.82875.89.
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, also known as statins, are the cornerstones of treatment of hyperlipidemia. They are widely used drugs that have well-documented, advantageous effects on cholesterol and atherosclerosis. The pleiotropic activities of statins can lead to newer applications. This review describes some of the available evidence supporting the use of statins for the treatment of acute coronary syndrome, as adjuncts to percutaneous coronary intervention, and for the prevention of sepsis. It also briefly discusses the rationale behind the potential development of statin-eluting stents.
3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂，也被称为他汀类药物，是高脂血症治疗的基石。它们是广泛使用的药物，对胆固醇和动脉粥样硬化具有充分记录的有益作用。他汀类药物的多效性活动可带来新的应用。本综述描述了一些支持使用他汀类药物治疗急性冠状动脉综合征、作为经皮冠状动脉介入治疗辅助药物以及预防败血症的现有证据。它还简要讨论了他汀洗脱支架潜在开发背后的基本原理。
