Bugamelli S, Zangheri E, Montebugnoli M, Borghi B, Ricci A, De Simone N, Bonfatti M, Elmar K, Luppi M, Pignotti E
Department of Anesthesiology, and Intensive Care IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy.
Minerva Anestesiol. 2007 Jan-Feb;73(1-2):57-64.
The aim of the study was to determine the doses of ropivacaine combined with mepivacaine for sciatic nerve blockade to enable the extension of analgesia without prolonged motor blockade, for the management of very painful operations in one-day surgery.
After obtaining approval by the ethics committee and written informed consent, we recruited 30 ASA I-III patients undergoing corrective orthopedic surgery of the forefoot in one-day surgery with sciatic nerve blockade. The patients were randomly divided into 3 groups: one control group, treated by 1.5% mepivacaine (300 mg), and two groups differentiated by the dose of 0.5% ropivacaine (25 and 40 mg) used in combination with 1.5% mepivacaine (225 mg). The offset data of the blockade were obtained by a self-assessment form filled in by the patients, and a direct check on discharge by a blinded observer.
There was no significant difference in the duration of the blockade among the 3 groups; the extension of analgesia was significant (P<0.003) in the group treated by mepivacaine+ropivacaine 40 mg (mean 477+/-255 min).
Adequate doses of ropivacaine added to mepivacaine for peripheral blockade produce and increase the duration of analgesia without influencing the criteria for discharge after Day Surgery.
本研究旨在确定罗哌卡因与甲哌卡因联合用于坐骨神经阻滞的剂量,以便在一日手术中管理非常疼痛的手术时,在不延长运动阻滞的情况下延长镇痛时间。
在获得伦理委员会批准并取得书面知情同意后,我们招募了30例接受一日手术中前足矫形手术并进行坐骨神经阻滞的ASA I - III级患者。患者被随机分为3组:一组为对照组,接受1.5%甲哌卡因(300 mg)治疗,另外两组根据与1.5%甲哌卡因(225 mg)联合使用的0.5%罗哌卡因剂量(25和40 mg)区分。通过患者填写的自我评估表以及由盲法观察者在出院时进行直接检查来获取阻滞的消退数据。
3组之间的阻滞持续时间无显著差异;在接受甲哌卡因 + 40 mg罗哌卡因治疗的组中,镇痛延长显著(P<0.003)(平均477±255分钟)。
在甲哌卡因中添加足够剂量的罗哌卡因用于外周阻滞可产生并延长镇痛时间,且不影响日间手术后的出院标准。