Cirulli Vincenzo, Yebra Mayra
University of California San Diego, Department of Pediatrics, National Center for Microscopy and Imaging Research, Whittier Institute for Diabetes, La Jolla, California 92037, USA.
Nat Rev Mol Cell Biol. 2007 Apr;8(4):296-306. doi: 10.1038/nrm2142. Epub 2007 Mar 14.
Named after the Sanskrit word netr, which means 'one who guides', the netrin family of secreted proteins provides migrational cues in the developing central nervous system. Recently, netrins have also been shown to regulate diverse processes (such as cell adhesion, motility, proliferation, differentiation and, ultimately, cell survival) in a number of non-neuronal tissues. In some cases, netrins affect these functions through non-classic netrin receptors, prompting a renewed interest in these factors in and beyond the nervous system.
分泌蛋白netrin家族以梵文单词netr命名，意为“引导者”，在发育中的中枢神经系统中提供迁移线索。最近，netrins也被证明在许多非神经组织中调节多种过程（如细胞黏附、运动、增殖、分化以及最终的细胞存活）。在某些情况下，netrins通过非经典的netrin受体影响这些功能，这引发了人们对神经系统内外这些因子的新兴趣。
