Sanders Mark
Pharmaxis Ltd.
Prim Care Respir J. 2007 Apr;16(2):71-81. doi: 10.3132/pcrj.2007.00017.
Inhalation has been employed as a method for delivering medications for more than two thousand years, and the benefits of delivering medication directly to the affected site - the lungs - have been understood for more than two hundred years. At the beginning of the Industrial Revolution, physicians were inventing therapies and experimenting with ideas for devices: it was a time of great creativity. However, by the end of the period the scientist and the regulated pharmaceutical industry had emerged and the role of the physician had been constrained. Few of the devices invented then remain in use today, but many of the principles used are still embodied in modern devices. This review traces the developments produced by the early pioneers who applied their creative thoughts to inhalation therapy, and examines how inhaled drug delivery has progressed. The devices pictured are from www.inhalatorium.com, an online museum of inhalation technologies.
吸入作为一种给药方法已被使用了两千多年，而将药物直接输送到受影响部位——肺部——的益处也已被认识了两百多年。在工业革命初期，医生们正在发明治疗方法并试验各种器械的想法：那是一个极具创造力的时代。然而，到这个时期结束时，科学家和规范的制药行业已经出现，医生的角色受到了限制。当时发明的器械如今很少仍在使用，但所采用的许多原理仍体现在现代器械中。这篇综述追溯了早期先驱者将他们的创造性思维应用于吸入疗法所带来的发展，并审视了吸入药物递送是如何取得进展的。图中的器械来自www.inhalatorium.com，这是一个吸入技术在线博物馆。
