Wood P J, Stratford I J, Sansom J M, Cattanach B M, Quinney R M, Adams G E
MRC Radiobiology Unit, Didcot, Oxon, U.K.
Int J Radiat Oncol Biol Phys. 1992;22(3):473-6. doi: 10.1016/0360-3016(92)90856-d.
31P magnetic resonance spectroscopy has been used to compare the effects of the vasoactive agents hydralazine and flunarizine on the oxygenation of the transplantable tumors, SCCVII/Ha and 16C, and a range of spontaneous mammary tumors arising in the breeding stock in the Genetics Division at the Radiobiology Unit. The vasodilator hydralazine, previously shown to increase the radiobiological hypoxic fraction of transplantable murine tumors, increased inorganic phosphate to total phosphate (Pi/total) in SCCVII/Ha and 16C tumors. However, only two spontaneous tumors responded to this agent (2/12). The calcium antagonist flunarizine, which sensitizes the SCCVII tumor to X rays, consistent with a reduction in hypoxic fraction, reduced Pi/total in this and the 16C tumor. Further, most spontaneous tumors tested (8/10) responded to this agent, as measured by a reduction in Pi/total. These results point to fundamental differences between transplantable and spontaneously arising tumors in mice in their response to vasoactive agents.
31P磁共振波谱已被用于比较血管活性药物肼屈嗪和氟桂利嗪对可移植肿瘤SCCVII/Ha和16C以及放射生物学单位遗传学部繁殖种群中一系列自发性乳腺肿瘤氧合作用的影响。血管扩张剂肼屈嗪先前已被证明可增加可移植小鼠肿瘤的放射生物学缺氧分数，它使SCCVII/Ha和16C肿瘤中的无机磷酸盐与总磷酸盐之比（Pi/总）升高。然而，只有两种自发性肿瘤对该药物有反应（2/12）。钙拮抗剂氟桂利嗪可使SCCVII肿瘤对X射线敏感，这与缺氧分数降低一致，它降低了该肿瘤以及16C肿瘤中的Pi/总。此外，通过Pi/总降低来衡量，大多数测试的自发性肿瘤（8/10）对该药物有反应。这些结果表明，小鼠可移植肿瘤和自发性肿瘤对血管活性药物的反应存在根本差异。
