Zhu Jiang, Wang Yan, Diao Yongshu
Cancer Center of West China Hospital, Center of Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 Feb;21(2):188-93.
To review the latest development of the research on the self-renwal signaling pathway and culture system in vitro of the embryonic stem cells (ESCs).
The recent articles about the self-renewal signaling pathway and culture system in vitro of the ESCs were extensively reviewed.
Understanding of the molecular mechanism of the self-renewal in vitro and pluripotency of the ESCs was considered important for developing improved methods of deriving, culturing and differentiating these cells into the cells that could be successfully used in the clinical practice.
A further research is needed to elucidate the self-renewal signaling pathway and the pluripotency of the ESCs and the culture system in vitro for the human ESCs remains to be further improved and developed.
综述胚胎干细胞（ESCs）自我更新信号通路及体外培养体系的研究最新进展。
广泛查阅近期有关ESCs自我更新信号通路及体外培养体系的文章。
了解ESCs体外自我更新的分子机制及其多能性，对于开发改进的ESCs获取、培养方法以及将其分化为可成功应用于临床实践的细胞的方法具有重要意义。
需要进一步研究以阐明ESCs的自我更新信号通路及其多能性，并且人ESCs的体外培养体系仍有待进一步改进和完善。
