Luján Irastorza Jesús Estuardo, García Rodríguez Francisco, Figueroa Preciado Gudelia, Hernández Marín Imelda, Ayala Aquiles R
Departamento de Biología de la Reproducción Humana, Dirección de Investigacíon y Enseñanza, Hospital Juárez de México SSA, DF.
Ginecol Obstet Mex. 2006 Nov;74(11):568-72.
Most of the information in medical literature report diverse factors of breast cancer, which are related to the reproductive life of the woman. It is mentioned that menarche before the 12 years elevates the relative risk of this disease, in comparison with its appearance after the 13 years.
To determine if early menarche is a risk factor associated to breast cancer.
This retrospective, observational and descriptive study included 162 women with breast cancer from a 3 years period (2002-2004), in the Juarez Hospital of Mexico. In addition other well known risk factors for breast cancer were evaluated. The statistical analysis was made with the software program SPSS; the descriptive analysis was made by means of summary of statistics, histograms, box and bar charts.
Early menarche doesn't have correlation with breast cancer nor with the appearance of the disease in early ages; it was present in the 12.3% (n = 20) of the patients; the menarche initiated between 12 and 13 years in 64.4% (n = 104.3) of the cases. The average age at the time of the diagnosis of breast cancer in the early menarche group was of 55 years and for the group in general of 47.6 years. The factor that seems to be related to breast cancer is overweight and obesity with 54.26 and 17.11% respectively, with an average body mass index of 27.7 kg/m2.
There was not a correlation between early menarche as risk factor for breast cancer neither between the reproductive risk factors considered habitual and increased risk of breast cancer. Overweight and obesity seem to be related to the appearance of the disease, reason why it is required to investigate this with different random control groups in the country. We propose to study other factors that may be implicated in the genesis of breast cancer such as inflammatory factors, similar insulin growth factors and hyperinsulinism.
医学文献中的大多数信息报道了乳腺癌的多种因素，这些因素与女性的生殖生活有关。据提及，与13岁之后初潮相比，12岁之前初潮会增加患这种疾病的相对风险。
确定初潮过早是否为与乳腺癌相关的风险因素。
这项回顾性、观察性和描述性研究纳入了墨西哥华雷斯医院3年期间（2002 - 2004年）的162例乳腺癌女性患者。此外，还评估了其他众所周知的乳腺癌风险因素。使用SPSS软件程序进行统计分析；描述性分析通过统计汇总、直方图、箱线图和柱状图进行。
初潮过早与乳腺癌以及疾病在早期出现均无相关性；初潮过早出现在12.3%（n = 20）的患者中；64.4%（n = 104.3）的病例初潮始于12至13岁之间。初潮过早组乳腺癌诊断时的平均年龄为55岁，总体组为47.6岁。似乎与乳腺癌相关的因素是超重和肥胖，分别为54.26%和17.11%，平均体重指数为27.7 kg/m²。
初潮过早作为乳腺癌风险因素与所考虑的习惯性生殖风险因素和乳腺癌风险增加之间均无相关性。超重和肥胖似乎与疾病的出现有关，因此需要在该国不同的随机对照组中对此进行研究。我们建议研究其他可能与乳腺癌发生有关的因素，如炎症因素、类似胰岛素生长因子和高胰岛素血症。
