Zhou Wei, Wang Tao, Zhu Lingjuan, Wen Minghua, Hu Lihua, Huang Xiao, You Chunjiao, Li Juxiang, Wu Yanqing, Wu Qinghua, Bao Huihui, Cheng Xiaoshu
Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Int J Hypertens. 2019 Nov 3;2019:9473182. doi: 10.1155/2019/9473182. eCollection 2019.
Association between age at menarche (AAM) and hypertension remains a controversial topic, and data in China were sparse. Therefore, we aimed to investigate the association between AAM and hypertension in Chinese female population.
In this cross-sectional study, 5,102 females aged ≥15 years were enrolled. Self-reported AAM was assessed by the questionnaire. Multiple linear regression analysis was used to evaluate the association between systolic blood pressure (SBP), diastolic blood pressure (DBP), and AAM. Logistic regression analysis was performed to evaluate the association between hypertension and AAM. Generalized additive model (GAM) and smooth curve fitting (penalized spline method) were conducted to explore the exact shape of curve between them.
The overall mean of AAM was 15.5 years. Each additional year of AAM was associated with a 15% higher risk of hypertension (odds ratio (OR) = 1.15, 95% confidence interval (CI): 1.11-1.19). Among females with hypertension, there was a significant positive association between AAM and SBP ( = 0.88, 95% CI: 0.29-1.46) and DBP ( = 0.80, 95% CI: 0.47-1.13). A significantly higher risk of hypertension was found in younger subjects (15-44 y: OR = 1.37, 95% CI: 1.21-1.55; for interaction = 0.009) compared with those aged between 62 and 97 y.
AAM was positively associated with hypertension and blood pressure, especially among females in early adulthood from southern China.
初潮年龄（AAM）与高血压之间的关联仍是一个有争议的话题，中国的相关数据较少。因此，我们旨在调查中国女性人群中AAM与高血压之间的关联。
在这项横断面研究中，纳入了5102名年龄≥15岁的女性。通过问卷调查评估自我报告的AAM。采用多元线性回归分析评估收缩压（SBP）、舒张压（DBP）与AAM之间的关联。进行逻辑回归分析以评估高血压与AAM之间的关联。采用广义相加模型（GAM）和平滑曲线拟合（惩罚样条法）来探索它们之间曲线的精确形状。
AAM的总体均值为15.5岁。AAM每增加一岁，患高血压的风险就会增加15%（优势比（OR）=1.15，95%置信区间（CI）：1.11-1.19）。在患有高血压的女性中，AAM与SBP（=0.88，95%CI：0.29-1.46）和DBP（=0.80，95%CI：0.47-1.13）之间存在显著的正相关。与62至97岁的女性相比，年轻受试者（15-44岁：OR=1.37，95%CI：1.21-1.55；交互作用P=0.009）患高血压的风险显著更高。
AAM与高血压和血压呈正相关，尤其是在中国南方成年早期的女性中。
Zotero 插件