Allen Camilla T, Sonnen Joshua, Leslie Mira J, Kidoguchi Lara, Harris Carrie, Gambetti Pierluigi, Montine Thomas J
Department of Pathology, University of Washington, Seattle, WA 98104, USA.
Ann Neurol. 2007 Apr;61(4):371-2. doi: 10.1002/ana.21096.
In February 2004, we initiated an epidemiological investigation within a US state to enhance autopsy surveillance for clinically suspected prion disease. During the first 30 months, 30 cases of suspected prion disease were referred from throughout Washington. Of these, 18 cases had prion disease, and all of these were classified as either familial or sporadic Creutzfeldt-Jakob disease (CJD); there was no case of variant CJD. This represents a death rate of approximately 1.1 cases of sporadic CJD per 1 million people per year in Washington. Our results do not support the hypotheses that variant CJD is an emerging illness in Washington or that sporadic CJD is more common in this state than in other regions of the world.
2004年2月，我们在美国一个州内开展了一项流行病学调查，以加强对临床疑似朊病毒病的尸检监测。在最初的30个月里，华盛顿州各地转诊了30例疑似朊病毒病病例。其中，18例患有朊病毒病，所有这些病例均被归类为家族性或散发性克雅氏病（CJD）；没有变异型CJD病例。这意味着华盛顿州每年每100万人中散发性CJD的死亡率约为1.1例。我们的结果不支持以下假设：变异型CJD在华盛顿州是一种新出现的疾病，或者散发性CJD在该州比世界其他地区更常见。
